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<\/figure>\n

\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u4e3a\u56ca\u6027\u7ea4\u7ef4\u5316\u6cbb\u7597\u5e26\u6765\u65b0\u5e0c\u671b<\/b> <\/strong><\/p>\n

CRISPR\u4e0e\u78b1\u57fa\u7f16\u8f91\u6280\u672f\u7cbe\u51c6\u4fee\u590dCFTR\u57fa\u56e0<\/b>
\n\u56ca\u6027\u7ea4\u7ef4\u5316\uff08Cystic Fibrosis, CF\uff09\u662f\u4e00\u79cd\u7531CFTR\u57fa\u56e0\u7a81\u53d8<\/b>\u5f15\u8d77\u7684\u9057\u4f20\u75c5\uff0c\u5bfc\u81f4\u60a3\u8005\u80ba\u90e8\u3001\u6d88\u5316\u7cfb\u7edf\u7b49\u5668\u5b98\u529f\u80fd\u53d7\u635f\u3002\u8fd1\u5e74\u6765\uff0cCRISPR\u57fa\u56e0\u7f16\u8f91\u6280\u672f<\/b>\u548c\u78b1\u57fa\u7f16\u8f91\uff08Base Editing\uff09<\/b>\u6210\u4e3a\u7814\u7a76\u70ed\u70b9\u3002\u79d1\u5b66\u5bb6\u901a\u8fc7\u9776\u5411\u4fee\u590dCFTR\u57fa\u56e0\u4e2d\u7684\u7279\u5b9a\u7a81\u53d8\uff0c\u6210\u529f\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u6062\u590d\u4e86\u86cb\u767d\u8d28\u529f\u80fd\u3002\u4f8b\u5982\uff0c\u4e00\u9879\u7814\u7a76\u5229\u7528\u78b1\u57fa\u7f16\u8f91\u7cfb\u7edf\u63d2\u5165\u201c\u56de\u590d\u7a81\u53d8\u201d\uff0c\u4f7fCFTR\u86cb\u767d\u91cd\u65b0\u53d1\u6325\u4f5c\u7528\uff0c\u4e3a\u6839\u6cbb\u75be\u75c5\u63d0\u4f9b\u4e86\u53ef\u80fd\u3002 <\/p>\n

Prime Editing\uff1a\u66f4\u9ad8\u6548\u7387\u7684\u57fa\u56e0\u4fee\u6b63\u65b9\u6848<\/b> <\/strong><\/p>\n

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\u5438\u5165\u5f0f\u57fa\u56e0\u7597\u6cd5\uff1a\u65e0\u521b\u6cbb\u7597\u7684\u65b0\u65b9\u5411<\/b> <\/strong><\/p>\n

\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\uff08UCLA\uff09\u7684\u56e2\u961f\u6b63\u5728\u5f00\u53d1\u4e00\u79cd\u5438\u5165\u5f0f\u57fa\u56e0\u7597\u6cd5<\/b>\uff0c\u901a\u8fc7\u96fe\u5316\u9012\u9001CRISPR\u7ec4\u4ef6\u81f3\u80ba\u90e8\uff0c\u76f4\u63a5\u4fee\u590d\u547c\u5438\u9053\u4e0a\u76ae\u7ec6\u80de\u7684CFTR\u57fa\u56e0\u3002\u8fd9\u79cd\u975e\u4fb5\u5165\u6027\u65b9\u6cd5\u53ef\u51cf\u5c11\u5168\u8eab\u6027\u526f\u4f5c\u7528\uff0c\u5e76\u9776\u5411\u75c5\u7076\u533a\u57df\u3002\u52a8\u7269\u5b9e\u9a8c\u663e\u793a\uff0c\u8be5\u6280\u672f\u80fd\u6709\u6548\u6539\u5584\u80ba\u529f\u80fd\uff0c\u9884\u8ba12025\u5e74\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002 <\/p>\n

\u4e34\u5e8a\u8f6c\u5316\u6311\u6218\u4e0e\u672a\u6765\u5c55\u671b<\/b> <\/strong><\/p>\n

\u5c3d\u7ba1\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u524d\u666f\u5e7f\u9614\uff0c\u4f46\u9012\u9001\u6548\u7387<\/b>\u3001\u514d\u75ab\u53cd\u5e94<\/b>\u548c\u957f\u671f\u5b89\u5168\u6027<\/b>\u4ecd\u662f\u5173\u952e\u969c\u788d\u3002\u4f8b\u5982\uff0c\u5982\u4f55\u786e\u4fdd\u7f16\u8f91\u5de5\u5177\u7cbe\u51c6\u5230\u8fbe\u76ee\u6807\u7ec6\u80de\uff0c\u5e76\u907f\u514d\u8131\u9776\u6548\u5e94\uff1f\u6b64\u5916\uff0cCRISPR-Cas9<\/b>\u548cPrime Editing<\/b>\u7684\u6210\u672c\u95ee\u9898\u4e5f\u9700\u89e3\u51b3\u3002\u76ee\u524d\uff0c\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8bc4\u4f30\u8fd9\u4e9b\u6280\u672f\u7684\u53ef\u884c\u6027\uff0c\u672a\u6765\u53ef\u80fd\u7ed3\u5408\u7eb3\u7c73\u8f7d\u4f53\u6216\u75c5\u6bd2\u9012\u9001\u7cfb\u7edf\u4f18\u5316\u6cbb\u7597\u3002 <\/p>\n

\u5168\u7403\u7814\u7a76\u8fdb\u5c55\u4e0e\u534f\u4f5c<\/b> <\/strong><\/p>\n

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\n\u7ed3\u8bed<\/b>
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